Type
Article
Title
The Minasarc study: A case-control study measuring mineral exposome in sarcoidosis
In
European Respiratory Journal
Author(s)
VINCENT Michel - Sciences Po (Author)
CAVALIN Catherine - Centre d'études européennes et de politique comparée (Author)
CATINON Mickaël - (Author)
CHEMARIN Cécile - Service pneumologie, oncologie thoracique, pathologie du sommeil (Author)
RIO Stéphane - Hôpital Saint Joseph (Author)
ROUX Elisabeth - École supérieure du professorat et de l'éducation - Académie de Versailles (Author)
PECQUET Mathieu - Hôpital Saint Joseph (Author)
BLANCHET Anne-Sophie - Université de Bordeaux (Author)
VUILLERMOZ Sylvie - Hôpital Saint Joseph (Author)
NATALIZIO Audrey - (Author)
PISON Christophe - (Author)
ARBIB François - Clinique de pneumologie (Author)
BONNETERRE Vincent - (Author)
VALEYRE Dominique - (Author)
FREYNET Olivia - Service de Pneumologie [Bichat] (Author)
MORNEX Jean-François - (Author)
FREYMOND Nathalie - Centre Hospitalier Lyon Sud [CHU - HCL] (Author)
PACHECO Yves - (Author)
THIVOLET Françoise - (Author)
KAMBOUCHNER Marianne - Service d’anatomie pathologique (Author)
BERNAUDIN Jean-François - (Author)
ROSENTAL Paul-Andre - Centre d'histoire de Sciences Po (Author)
Editor
Lausanne : European Respiratory Society
Volume
48
Number
suppl 60
ISSN
09031936
Keywords
Sarcoidosis, Occupation, Interstitial lung disease
Abstract
EN
It has been suggested that sarcoidosis could be associated with exposure to inorganic particles (Newman LS Curr Opin All Clin Immunol 2012; 12:145-50, Vincent M et al Am J Ind Med 2015; 58:S31-8). In order to test this hypothesis the Minasarc study was designed to evaluate the mineral exposome by a specific questionnaire (SQ) and a mineralogical analysis performed on BALs by optical and electron microscopy in patients and healthy volunteers (HV). We present here the results obtained by the SQ which can be considered as a tool for global assessment of the “whole life” exposure to inorganic particles in occupational and environmental contexts. The study was performed on 20 patients with sarcoidosis and 20 HV. Every HV was matched to a patient by sex, age and smoking habit. The SQ was calibrated with a representative sample of the French population (n=825) in the ELIPSSilice survey (ANR-10-Eqpx-19-01) and the result was expressed as a “dust score”. Scores were compared by a Wilcoxon signed-rank test. [Résumé éditeur]

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