Type
Article
Titre
Sarcoidosis, inorganic dust exposure and content of bronchoalveolar lavage fluid: the MINASARC pilot study
Dans
Sarcoidosis, Vasculitis and Difusse Lung Diseases
Auteur(s)
CAVALIN Catherine - Centre d'études européennes et de politique comparée (Auteur)
CATINON Mickaël - (Auteur)
CHEMARIN Cécile - Service pneumologie, oncologie thoracique, pathologie du sommeil (Auteur)
ROUX Elisabeth - École supérieure du professorat et de l'éducation - Académie de Versailles (Auteur)
PECQUET Mathieu - (Auteur)
BLANCHET Anne-Sophie - Université de Bordeaux (Auteur)
VUILLERMOZ Sylvie - (Auteur)
PISON Christophe - (Auteur)
ARBIB François - Clinique de pneumologie (Auteur)
BONNETERRE Vincent - (Auteur)
VALEYRE Dominique - (Auteur)
FREYNET Olivia - Service de Pneumologie [Bichat] (Auteur)
MORNEX Jean-François - (Auteur)
PACHECO Yves - (Auteur)
FREYMOND Nathalie - Centre Hospitalier Lyon Sud [CHU - HCL] (Auteur)
THIVOLET Françoise - (Auteur)
KAMBOUCHNER Marianne - Service d’anatomie pathologique (Auteur)
BERNAUDIN Jean-François - (Auteur)
NATHALIZIO Audrey - (Auteur)
PRADAT Pierre - (Auteur)
ROSENTAL Paul-Andre - Centre d'histoire de Sciences Po (Auteur)
VINCENT Michel - Sciences Po (Auteur)
Éditeur
Maurizio Mattioli editore
Numéro
35
Pages
327 - 332 p.
ISSN
11240490
Résumé
EN
Inhalation of mineral dust was suggested to contribute to sarcoidosis. We compared the mineral exposome of 20 sarcoidosis and 20 matched healthy subjects. Bronchoalveolar lavage (BAL) samples were treated by digestion-filtration and analyzed by transmission electron microscopy. The chemical composition of inorganic particles was determined by energy-dispersive X-ray (EDX) spectroscopy. Dust exposure was also assessed by a specific questionnaire. Eight sarcoidosis patients and five healthy volunteers had a high dust load in their BAL. No significant difference was observed between the overall inorganic particle load of each group while a significant higher load for steel was observed in sarcoidosis patients (p=0.029). Moreover, the building activity sub-score was significantly higher in sarcoidosis patients (p=0.018). These results suggest that building work could be a risk factor for sarcoidosis which could be considered at least in some cases as a granulomatosis caused by airborne inorganic dust. The questionnaire should be validated in larger studies.

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